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Nature:人造甜味剂的有害作用

摘要 : 在小鼠和人类的分析表明,无热量人造甜味剂通过改变肠道细菌的功能,可以促进肥胖相关的代谢变化。相关文章发表于2014年9月17日的《Nature》杂志上。
糖精直接调控微生物

糖精直接调控微生物

我们使用不含热量的人造甜味剂已经超过一个世纪了。今天食品工业将它们用在食品中的数量越来越大,同时它们也被推荐用于减肥和供患葡萄糖耐受不良及2-型糖尿病的人使用。

Eran Elinav及同事发现,三种最常用的不含热量的人造甜味剂(糖精、三氯蔗糖和阿斯巴甜)的消耗,会直接诱发小鼠产生肥胖和葡萄糖耐受不良倾向。这些效应由小肠微生物群的组成和功能的变化调节,有害代谢效应可以通过“粪便移植”转移给无菌小鼠,并可通过抗生素治疗被消除。

作者显示,人造甜味剂能诱发健康人士发生菌群失调和葡萄糖耐受不良。他们提出,可能有必要制定专门针对个体以及针对肠道微生物群变化的新的营养策略。

原文摘要:

Artificial sweeteners induce glucose intolerance by altering the gut microbiota

Jotham Suez, Tal Korem, David Zeevi, Gili Zilberman-Schapira, Christoph A. Thaiss, Ori Maza, David Israeli, Niv Zmora, Shlomit Gilad, Adina Weinberger, Yael Kuperman, Alon Harmelin, Ilana Kolodkin-Gal, Hagit Shapiro, Zamir Halpern, Eran Segal & Eran Elinav

Non-caloric artificial sweeteners (NAS) are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike. NAS consumption is considered safe and beneficial owing to their low caloric content, yet supporting scientific data remain sparse and controversial. Here we demonstrate that consumption of commonly used NAS formulations drives the development of glucose intolerance through induction of compositional and functional alterations to the intestinal microbiota. These NAS-mediated deleterious metabolic effects are abrogated by antibiotic treatment, and are fully transferrable to germ-free mice upon faecal transplantation of microbiota configurations from NAS-consuming mice, or of microbiota anaerobically incubated in the presence of NAS. We identify NAS-altered microbial metabolic pathways that are linked to host susceptibility to metabolic disease, and demonstrate similar NAS-induced dysbiosis and glucose intolerance in healthy human subjects. Collectively, our results link NAS consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage.

对应Nature杂志: 2014年10月9日Nature杂志精选

来源: Nature中文 浏览次数:326

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