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Nature:肝硬化与肠道微生物群的联系

摘要 : 浙江大学等处的研究人员在近日的一项研究中表明,以微生物为目标的生物标志物可能是不同的疾病诊断的一个强大工具。相关文章发表于2014年7月23日的《Nature》杂志上。
健康的中国人的MGS丰度为(N=114),丹麦人为(N=292)。

健康的中国人的MGS丰度为(N=114),丹麦人为(N=292)。

以前的研究工作显示,在肝脏并发症如肝硬化与肠道微生物群之间存在一个联系。

Lanjuan Li 及同事对来自98个肝硬化患者和83个健康对照组成员的粪便样本进行了一项全微生物群关联研究。定量元基因组分析显示,75,245个基因的丰度在这两组人之间显著不同,其中很多可以被归入代表先天同源细菌种类的66个类别中。

在这些细菌中,28种在肝硬化患者体内富集,大部分来源于口腔(主要是韦荣球菌和链球菌)。所识别出的标记是独特的、肝硬化特定的基因,同时作者还发现:这些基因当中一组仅仅15个就可以构成可用作诊断工具的一个高度准确的辨别指标的基础。

原文摘要:

Alterations of the human gut microbiome in liver cirrhosis

Nan Qin, Fengling Yang, Ang Li, Edi Prifti, Yanfei Chen, Li Shao, Jing Guo, Emmanuelle Le Chatelier, Jian Yao, Lingjiao Wu, Jiawei Zhou, Shujun Ni, Lin Liu, Nicolas Pons, Jean Michel Batto, Sean P. Kennedy, Pierre Leonard, Chunhui Yuan, Wenchao Ding, Yuanting Chen, Xinjun Hu, Beiwen Zheng, Guirong Qian, Wei Xu, S. Dusko Ehrlich et al.

Liver cirrhosis occurs as a consequence of many chronic liver diseases that are prevalent worldwide. Here we characterize the gut microbiome in liver cirrhosis by comparing 98 patients and 83 healthy control individuals. We build a reference gene set for the cohort containing 2.69 million genes, 36.1% of which are novel. Quantitative metagenomics reveals 75,245 genes that differ in abundance between the patients and healthy individuals (false discovery rate < 0.0001) and can be grouped into 66 clusters representing cognate bacterial species; 28 are enriched in patients and 38 in control individuals. Most (54%) of the patient-enriched, taxonomically assigned species are of buccal origin, suggesting an invasion of the gut from the mouth in liver cirrhosis. Biomarkers specific to liver cirrhosis at gene and function levels are revealed by a comparison with those for type 2 diabetes and inflammatory bowel disease. On the basis of only 15 biomarkers, a highly accurate patient discrimination index is created and validated on an independent cohort. Thus microbiota-targeted biomarkers may be a powerful tool for diagnosis of different diseases.

扩展阅读:浙大发现与肝硬化相关的肠道菌群遗传特征

对应Nature杂志: 2014年9月4日Nature杂志精选

来源: Nature 浏览次数:199

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