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Nature Nanotechnology:绿茶不仅养生,将来也可用于治癌

标签:抗癌
摘要 : 新加坡科学家最近发现绿茶中的一种有效成分能够作为潜在的纳米载药系统用于输送蛋白药物以治疗癌症。

 新加坡科学家最近发现绿茶中的一种有效成分能够作为潜在的纳米载药系统用于输送蛋白药物以治疗癌症。在动物试验中,研究人员利用这种名为没食子酸(EGCG)的抗氧化剂来装载罗氏和基因泰克的抗乳腺癌药物Herceptin,相比于对照组,载药系统组疗效超出了两倍之多。同时,通过载药系统包载后,药物在肝脏和肾脏的积累降低了70%左右,在肺部的积累降低了40%。这一研究已经被发表在著名期刊 Nature Nanotechnology上。

一直以来,EGCG都只被认为是绿茶中的一种有益成分,而它的载药系统功能则是最近才被发现的。研究人员将EGCG和聚乙二醇结合起来,使得EGCG能够保护蛋白质药物不被降解。负责这一研究的Jackie Ying介绍说,将绿茶中的有效成分应用到纳米医药领域尚属首次,而药物与载药系统的协同作用也令研究人员感到惊喜。

下一步,研究人员希望将这种载药系统拓展到个性化治疗和健康食品方面。

原文摘要:

Self-assembled micellar nanocomplexes comprising green tea catechin derivatives and protein drugs for cancer therapy

Joo Eun Chung, Susi Tan, Shu Jun Gao, Nunnarpas Yongvongsoontorn, Soon Hee Kim, Jeong Heon Lee, Hak Soo Choi, Hirohisa Yano, Lang Zhuo, Motoichi Kurisawa & Jackie Y. Ying

When designing drug carriers, the drug-to-carrier ratio is an important consideration, because the use of high quantities of carriers can result in toxicity as a consequence of poor metabolism and elimination of the carriers1. However, these issues would be of less concern if both the drug and carrier had therapeutic effects. (?)-Epigallocatechin-3-O-gallate (EGCG), a major ingredient of green tea, has been shown, for example, to possess anticancer effects2, 3, 4, 5, 6, 7, anti-HIV effects8, neuroprotective effects9 and DNA-protective effects10. Here, we show that sequential self-assembly of the EGCG derivative with anticancer proteins leads to the formation of stable micellar nanocomplexes, which have greater anticancer effects in vitro and in vivo than the free protein. The micellar nanocomplex is obtained by complexation of oligomerized EGCG with the anticancer protein Herceptin to form the core, followed by complexation of poly(ethylene glycol)–EGCG to form the shell. When injected into mice, the Herceptin-loaded micellar nanocomplex demonstrates better tumour selectivity and growth reduction, as well as longer blood half-life, than free Herceptin.(doi:10.1038/nnano.2014.208

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