nature

当前位置: Nature » 神经科学 » 正文

Nature子刊:清华大学吴励研究组和厦门大学韩家淮课题组揭示树突状细胞抗原交叉递呈的重要作用

摘要 : 近日,国际学术权威刊物自然出版集团旗下子刊《Cellular & Molecular Immunology》杂志在线发表了清华大学医学院吴励教授研究组和厦门大学生命科学学院韩家淮教授课题组题为“p38α has an important role in antigen cross-presentation by dendritic cells”的最新合作研究成果

 近日,国际学术权威刊物自然出版集团旗下子刊《Cellular & Molecular Immunology》杂志在线发表了清华大学医学院吴励教授研究组和厦门大学生命科学学院韩家淮教授课题组题为“p38α has an important role in antigen cross-presentation by dendritic cells”的最新合作研究成果,研究论文揭示了p38α在树突状细胞抗原交叉递呈中的重要作用。吴励教授与韩家淮教授为这项工作的共同通讯作者。

树突状细胞是体内重要的抗原递呈细胞,能够有效地激活获得性免疫系统,抗原交叉递呈(cross-presentation)是树突状细胞激活获得型免疫系统的一个关键过程。p38α是一进化上高度保守的信号通路,在免疫系统中发挥重要作用,但其在树突状细胞中的功能尚未完全明了。在这项研究中,研究人员发现p38α特异性缺失的树突状细胞,其对于OVA抗原的抗原交叉递呈能力有着显著的下降。进一步的研究表明,对于抗原肽段刺激,树突状细胞中p38α的特异性缺失并不会影响抗原交叉递呈,表明p38α特异性影响了抗原的加工过程。深入的机制研究表明,p38α会影响Nox2等许多抗原加工蛋白的表达,从而影响对于抗原蛋白的加工。

原文链接:

p38α has an important role in antigen cross-presentation by dendritic cells

原文摘要:

The role of the p38 signaling pathway in the innate and adaptive immune responses has been well documented, especially in inflammatory cytokine production by dendritic cells (DCs). However, whether the p38 signaling pathway affects the important antigen (Ag) presentation function of DCs remains largely unknown. In this study, we reported that the deletion of p38α resulted in an impaired cross-presentation ability of CD8+conventional DCs (cDCs) and a reduction in the direct presentation ability of CD8− cDCs ex vivo. Further study revealed that p38α had a crucial role in Ag processing by CD8+ cDCs but did not affect the Ag uptake or co-stimulation of T cells. Moreover, p38α deficiency led to reduced cross-priming of T cells in vivo. The production of the IL-12p40 and IL-12p70 cytokines by p38α-deficient cDCs was also significantly reduced. Our study identified a new role for p38α in modulating the important antigen cross-presentation function of DCs.

来源: Cellular & Molecular Immunolog 浏览次数:0

热门文章TOP

RSS订阅 - 填写您的邮件地址,订阅我们的精彩内容: - 网站地图
网站联系电话:020-87540820 备案号:粤ICP备11050685号-8 增值电信业务经营许可证:粤B2-20120479
©2011-2015 生物帮 All rights reserved.