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Nature:果蝇体内的睡眠促进细胞

摘要 : 果蝇(Drosophila)的一些特定的昼夜节律神经元能促进运动活动的昼夜高峰,这些神经元的活动以24小时为周期,但它们在睡眠控制方面的作用尚不明确。

 果蝇(Drosophila)的一些特定的昼夜节律神经元能促进运动活动的昼夜高峰,这些神经元的活动以24小时为周期,但它们在睡眠控制方面的作用尚不明确。现在,Michael Rosbash及同事发现了一种叫做DN1s的背生物钟神经元,它们作为睡眠促进细胞,与起搏神经元共同参与了驱动午休和夜晚睡眠的反馈回路。他们还发现,DN1神经元活动在两性间存在差异,且会对温度作出反应,与上述因素影响白昼睡眠的效应一致。在本期《自然》中,Gero Miesenböck及同事还报告了支配果蝇扇形体的多巴胺能睡眠促进神经元会在电活性和电静息之间转换,这是睡眠需求的功能之一。

原文链接:

Circadian neuron feedback controls theDrosophila sleep–activity profile

原文摘要:

Little is known about the ability of Drosophila circadian neurons to promote sleep. Here we show, using optogenetic manipulation and video recording, that a subset of dorsal clock neurons (DN1s) are potent sleep-promoting cells that release glutamate to directly inhibit key pacemaker neurons. The pacemakers promote morning arousal by activating these DN1s, implying that a late-day feedback circuit drives midday siesta and night-time sleep. To investigate more plastic aspects of the sleep program, we used a calcium assay to monitor and compare the real-time activity of DN1 neurons in freely behaving males and females. Our results revealed that DN1 neurons were more active in males than in females, consistent with the finding that male flies sleep more during the day. DN1 activity is also enhanced by elevated temperature, consistent with the ability of higher temperatures to increase sleep. These new approaches indicate that DN1s have a major effect on the fly sleep–wake profile and integrate environmental information with the circadian molecular program.

来源: Nature 浏览次数:1

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