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摘要 : 本周发表在《科学报告》上的一则初步研究在患有阿兹海默症的病人的脑组织发现了真菌细胞和菌丝。


使用显微镜和抗真菌抗体,Luis Carrasco和他的研究团队检查了11位生前患有阿兹海默症的患者和10位对照组(生前没有患有阿兹海默症)的脑组织样本。研究者发现所有患有阿兹海默症的患者大脑中都有真菌细胞和其他真菌物质,但是对照组的大脑中没有一例有发现真菌。他们同时发现了真菌大分子物质,例如蛋白质和DNA,存在于患有阿兹海默症病人的血液样本中。研究者指出每个阿兹海默症患者体内的真菌形态都略有不同,说明患者体内的真菌物种可能各有不同。



Different Brain Regions are Infected with Fungi in Alzheimer’s Disease


The possibility that Alzheimer’s disease (AD) has a microbial aetiology has been proposed by several researchers. Here, we provide evidence that tissue from the central nervous system (CNS) of AD patients contain fungal cells and hyphae. Fungal material can be detected both intra- and extracellularly using specific antibodies against several fungi. Different brain regions including external frontal cortex, cerebellar hemisphere, entorhinal cortex/hippocampus and choroid plexus contain fungal material, which is absent in brain tissue from control individuals. Analysis of brain sections from ten additional AD patients reveals that all are infected with fungi. Fungal infection is also observed in blood vessels, which may explain the vascular pathology frequently detected in AD patients. Sequencing of fungal DNA extracted from frozen CNS samples identifies several fungal species. Collectively, our findings provide compelling evidence for the existence of fungal infection in the CNS from AD patients, but not in control individuals.

来源: Scientific Reports 浏览次数:0


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