nature

当前位置: Nature » 神经科学 » 正文

Sci.Rep:阿兹海默病患者大脑中的真菌感染

摘要 : 本周发表在《科学报告》上的一则初步研究在患有阿兹海默症的病人的脑组织发现了真菌细胞和菌丝。

 本周发表在《科学报告》上的一则初步研究在患有阿兹海默症的病人的脑组织发现了真菌细胞和菌丝。

使用显微镜和抗真菌抗体,Luis Carrasco和他的研究团队检查了11位生前患有阿兹海默症的患者和10位对照组(生前没有患有阿兹海默症)的脑组织样本。研究者发现所有患有阿兹海默症的患者大脑中都有真菌细胞和其他真菌物质,但是对照组的大脑中没有一例有发现真菌。他们同时发现了真菌大分子物质,例如蛋白质和DNA,存在于患有阿兹海默症病人的血液样本中。研究者指出每个阿兹海默症患者体内的真菌形态都略有不同,说明患者体内的真菌物种可能各有不同。

由于该研究中患有阿兹海默症患者的年龄都较大(62岁到92岁之间),研究者认为这些患者大脑出现真菌感染可能是由于较差的适应性免疫反应造成的。不过还需要进一步的临床研究来确立这种感染出现的原因。

原文链接:

Different Brain Regions are Infected with Fungi in Alzheimer’s Disease

原文摘要:

The possibility that Alzheimer’s disease (AD) has a microbial aetiology has been proposed by several researchers. Here, we provide evidence that tissue from the central nervous system (CNS) of AD patients contain fungal cells and hyphae. Fungal material can be detected both intra- and extracellularly using specific antibodies against several fungi. Different brain regions including external frontal cortex, cerebellar hemisphere, entorhinal cortex/hippocampus and choroid plexus contain fungal material, which is absent in brain tissue from control individuals. Analysis of brain sections from ten additional AD patients reveals that all are infected with fungi. Fungal infection is also observed in blood vessels, which may explain the vascular pathology frequently detected in AD patients. Sequencing of fungal DNA extracted from frozen CNS samples identifies several fungal species. Collectively, our findings provide compelling evidence for the existence of fungal infection in the CNS from AD patients, but not in control individuals.

来源: Scientific Reports 浏览次数:0

热门文章TOP

RSS订阅 - 填写您的邮件地址,订阅我们的精彩内容: - 网站地图
网站联系电话:020-87540820 备案号:粤ICP备11050685号-8 增值电信业务经营许可证:粤B2-20120479
©2011-2015 生物帮 All rights reserved.