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Nature:听觉相关的雄性特有神经元

摘要 : 线虫被研究很多的神经网络已通过详尽电子显微镜重建被全面标绘出来。

线虫被研究很多的神经网络已通过详尽电子显微镜重建被全面标绘出来。但现在,Arantza Barrios及同事发现了以前不知道的一对分布在两边的神经元,被称为MCMs,意即“雄性的神秘细胞”,它们是通过雄性线虫特有的神经胶质细胞在性成熟过程中发生的转分化(transdifferentiation)形成的。这些神经元是雄性特定的一种关联学习(这种学习方式对趋化反应与生殖优先级加以平衡)所必需的。这一发现表明,雄性特定神经元的增添会成为性成熟过程中重塑脑回路的一个有效方式。作者猜测,充当神经元祖细胞来建立高层次处理回路的能力有可能是神经胶质细胞的一个普遍性的、并且还可能是古老的功能。

原文链接:

Glia-derived neurons are required for sex-specific learning in C. elegans

原文摘要:

Sex differences in behaviour extend to cognitive-like processes such as learning, but the underlying dimorphisms in neural circuit development and organization that generate these behavioural differences are largely unknown. Here we define at the single-cell level—from development, through neural circuit connectivity, to function—the neural basis of a sex-specific learning in the nematode Caenorhabditis elegans. We show that sexual conditioning, a form of associative learning, requires a pair of male-specific interneurons whose progenitors are fully differentiated glia. These neurons are generated during sexual maturation and incorporated into pre-exisiting sex-shared circuits to couple chemotactic responses to reproductive priorities. Our findings reveal a general role for glia as neural progenitors across metazoan taxa and demonstrate that the addition of sex-specific neuron types to brain circuits during sexual maturation is an important mechanism for the generation of sexually dimorphic plasticity in learning.

来源: Nature 浏览次数:0

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