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Nat Com:治疗阿尔茨海默氏症的新方法

摘要 : 本期Nature Communications上发表的一项研究描述了治疗阿尔茨海默氏症的一个新的潜在方法。

 本期Nature Communications上发表的一项研究描述了治疗阿尔茨海默氏症的一个新的潜在方法。这项研究显示,通过以在调控身体免疫系统中起重要作用的特定白细胞(被称为调控性T-细胞)为治疗目标,阿尔茨海默氏症的关键症状在小鼠身上可以得到成功治疗。

阿尔茨海默氏症影响中枢神经系统,导致神经损伤、被称为斑块的蛋白块形成和慢性炎症。以前人们已经意识到,当将免疫细胞朝向中枢神经系统引导时,这些症状会减轻。

在这篇论文中,Michal Schwartz及同事显示,阻断特定T-细胞(被称为Foxp3+ Tregs)的活性,可以使更多免疫细胞超小鼠脑运动。因此,炎症和斑块会减少,实验鼠在认知试验中表现会更好。这项研究显示了调控性T-细胞在影响大脑的疾病中所起的一个作用。它也表明,这些细胞是未来治疗阿尔茨海默氏症的可能药物目标。

原文链接:

Breaking immune tolerance by targeting Foxp3+regulatory T cells mitigates Alzheimer’s disease pathology

原文摘要:

Alzheimer’s disease (AD) is a neurodegenerative disorder in which chronic neuroinflammation contributes to disease escalation. Nevertheless, while immunosuppressive drugs have repeatedly failed in treating this disease, recruitment of myeloid cells to the CNS was shown to play a reparative role in animal models. Here we show, using the 5XFAD AD mouse model, that transient depletion of Foxp3+ regulatory T cells (Tregs), or pharmacological inhibition of their activity, is followed by amyloid-β plaque clearance, mitigation of the neuroinflammatory response and reversal of cognitive decline. We further show that transient Treg depletion affects the brain’s choroid plexus, a selective gateway for immune cell trafficking to the CNS, and is associated with subsequent recruitment of immunoregulatory cells, including monocyte-derived macrophages and Tregs, to cerebral sites of plaque pathology. Our findings suggest targeting Treg-mediated systemic immunosuppression for treating AD.

来源: Nature Communications 浏览次数:1

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