当前位置: Nature » 神经科学 » 正文


摘要 : 瑞士弗里德里希·米歇尔生物医学研究所的研究人员以小鼠的经典条件化听觉恐惧为模型系统,识别出两个截然不同的与学习相关的非抑制性机制,涉及截然不同的中间神经元类群。相关文章发表于2014年5月11日的《Nature》杂志上。




以小鼠的经典条件化听觉恐惧为模型系统,Andreas Lüthi及同事识别出两个截然不同的与学习相关的非抑制性机制,涉及截然不同的中间神经元类群。


作者猜测,这一微回路中PV+ 和SOM+ 中间神经元的差异化调制,可能会允许根据行为情景和实验动物的内在状态来对学习进行灵活的调控。


Amygdala interneuron subtypes control fear learning through disinhibition

Steffen B. E. Wolff, Jan Gründemann, Philip Tovote, Sabine Krabbe, Gilad A. Jacobson,Christian Müller, Cyril Herry, Ingrid Ehrlich, Rainer W. Friedrich, Johannes J. Letzkus &Andreas Lüthi

Learning is mediated by experience-dependent plasticity in neuronal circuits. Activity in neuronal circuits is tightly regulated by different subtypes of inhibitory interneurons, yet their role in learning is poorly understood. Using a combination of in vivo single-unit recordings and optogenetic manipulations, we show that in the mouse basolateral amygdala, interneurons expressing parvalbumin (PV) and somatostatin (SOM) bidirectionally control the acquisition of fear conditioning—a simple form of associative learning—through two distinct disinhibitory mechanisms. During an auditory cue, PV+ interneurons are excited and indirectly disinhibit the dendrites of basolateral amygdala principal neurons via SOM+ interneurons, thereby enhancing auditory responses and promoting cue–shock associations. During an aversive footshock, however, both PV+ and SOM+interneurons are inhibited, which boosts postsynaptic footshock responses and gates learning. These results demonstrate that associative learning is dynamically regulated by the stimulus-specific activation of distinct disinhibitory microcircuits through precise interactions between different subtypes of local interneurons.

对应Nature杂志: 2014年5月22日Nature杂志精选

来源: Nature中文 浏览次数:96


RSS订阅 - 填写您的邮件地址,订阅我们的精彩内容: - 网站地图
网站联系电话:020-87540820 备案号:粤ICP备11050685号-8 增值电信业务经营许可证:粤B2-20120479
©2011-2015 生物帮 All rights reserved.