nature

当前位置: Nature » 分子生物学 » 正文

一种与糖相关的化学物质可延长小鼠的寿命

摘要 : 瑞士苏黎世联邦理工学院等处的研究人员在一项小鼠研究中发现,与糖相关的化学物质“D-葡糖胺”是通过模仿含碳水化合物低的一种饮食的分子效应产生这种寿命延长效果的。相关文章发表于2014年4月8日的《Nature Communications》杂志上。
Capsules

本期Nature Communications上发表的一篇研究论文报告说,关节炎患者广泛使用的一种饮食补充物能延长蠕虫和衰老小鼠的寿命。与糖相关的化学物质“D-葡糖胺”(该物质被认为对人类使用是安全的,购买无需处方)是通过模仿含碳水化合物低的一种饮食的分子效应产生这种寿命延长效果的。

能延长生物寿命的化学物质是人们迫切想得到的,但能够可重现地延长小鼠寿命的并不是很多,一般被认为对人类使用安全的就更少了。Michael Ristow及同事对比较“老”的、大概两岁的小鼠使用了氨基糖“D-葡糖胺”,发现对两种性别的小鼠它都能延长其寿命。通过研究该效应在蠕虫身上的机制基础,这些研究人员发现,“D-葡糖胺”能降低葡萄糖代谢和增加氨基酸周转。

鉴于“D-葡糖胺”早就被人类使用,甚至高剂量也普遍被认为是安全的,所以本文作者提出:“D-葡糖胺”有可能被广泛用作干预手段,来延长人类的健康时间或寿命。

原文摘要:

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

Sandra Weimer, Josephine Priebs, Doreen Kuhlow, Marco Groth, Steffen Priebe, Johannes Mansfeld, Troy L. Merry, Sébastien Dubuis, Beate Laube, Andreas F. Pfeiffer, Tim J. Schulz,Reinhard Guthke, Matthias Platzer, Nicola Zamboni, Kim Zarse & Michael Ristow

D-Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independent of the hexosamine pathway, extends Caenorhabditis elegans life span by impairing glucose me-tabolism that activates AMP-activated protein kinase (AMPK/AAK-2) and increases mitochondrial biogenesis. Consistent with the concept of mitohormesis, GlcN promotes increased formation of mitochondrial reactive oxygen species (ROS) culminating in increased expressi0n of the nematodal amino acid-transporter 1 (aat-1) gene. Ameliorating mitochondrial ROS formation or impairment of aat-1-expressi0n abolishes GlcN-mediated life span extension in an NRF2/SKN-1-dependent fashion. Unlike other calorie restriction mimetics, such as 2-deoxyglucose, GlcNextends life span of ageing C57BL/6 mice, which show an induction of mitochondrial biogenesis, lowered blood glucose levels, enhanced expressi0n of several murine amino-acid transporters, as well as increased amino-acid catabolism. Taken together, we provide evidence that GlcN extends life span in evolutionary distinct species by mimicking a low-carbohydrate diet.

来源: Nature Communications 浏览次数:94

热门文章TOP

RSS订阅 - 填写您的邮件地址,订阅我们的精彩内容: - 网站地图
网站联系电话:020-87540820 备案号:粤ICP备11050685号-8 增值电信业务经营许可证:粤B2-20120479
©2011-2015 生物帮 All rights reserved.