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Nature子刊:中科院深圳先进院喻学锋研究组发表二维材料肿瘤靶向放疗领域进展

摘要 : 近日,国际学术权威刊物自然出版集团旗下子刊《NPG Asia Materials》杂志在线发表了中国科学院深圳先进技术研究院喻学锋研究员课题组与暨南大学陈填烽教授等合作的一篇研究论文,论文报告研究组设计合成了一种二维片状结构的靶向纳米体系,实现了肿瘤靶向放射治疗。

近日,国际学术权威刊物自然出版集团旗下子刊《NPG Asia Materials》杂志在线发表了中国科学院深圳先进技术研究院喻学锋研究员课题组与暨南大学陈填烽教授等合作的一篇研究论文,论文报告研究组设计合成了一种二维片状结构的靶向纳米体系,实现了肿瘤靶向放射治疗。研究成果以题为“Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for invivo imaging guided cancer radiation therapy”(用于成像引导肿瘤放疗的超薄二维纳米诊疗制剂)。

放疗作为临床上最常用的肿瘤治疗方法,其疗效受到射线辐射剂量和增敏剂毒性的极大限制。因此,开发高效低毒且同时具备诊断与治疗功能的放疗制剂具有重大意义。喻学锋研究员团队之前在黑磷、硒化铋等二维材料的肿瘤诊疗领域取得了系列研究成果。前期研究发现,硒(Se)是人体必需的微量元素,硒化铋纳米片生物相容性好、并在体内可代谢(Small, 12, 4136, 2016);并且,硒化物纳米材料光热转换率高,且具备多重成像功能(Biomaterials. 11,4848, 2017),因此在肿瘤诊疗领域具有很好的应用潜力。

在本项工作中,研究团队利用铋(Bi,Z=83)大的X射线衰减性能,硒的表面等离子体共振效应、抗肿瘤活性、体内可降解性,设计合成了一种具有二维超薄Bi2Se3纳米片,利用其优良的光热转换效率,实现体内光声成像介导的肿瘤靶向放射治疗。经RGD多肽修饰后该纳米片表现出优越的肿瘤靶向能力、高效的放射增敏作用、体内可降解性和低的肝累积及肝毒性。进一步的增敏机制研究发现,RGD多肽修饰的硒化铋纳米片增敏放疗激活线粒体介导的内源性凋亡通路,在高能X射线作用下可促进细胞内超氧化物阴离子转化成单线态氧,对肿瘤细胞造成原发性损伤,抑制了TrxR活性破坏细胞内氧化还原平衡,抑制了细胞自我修复能力相关蛋白的表达,激活了DNA损伤介导的p53通路,最终引起细胞凋亡。这项研究为成像介导的肿瘤靶向放射治疗提供了一种有效的临床可行方法。

图 靶向硒化铋纳米片用于体内光声成像介导的肿瘤放射治疗设计思路图。

原文链接:

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

原文摘要:

An efficient radiotherapeutic agent is synthesized using ultrathin two-dimensional 30-nm-wide and 2-nm-thick Bi2Se3 nanosheets (NSs) as a radiosensitizer. Chitosan (CS) and RGD peptide are employed to enhance the radiotherapy efficiency and biocompatibility. The Bi2Se3-CS-RGD NSs exhibit excellent targeting ability to αvβ3 integrin-overexpressing cancer cells and potent radiosensitization efficiency with high stability. Detailed in vitro experiments show that the Bi2Se3-CS-RGD NSs enhance the sensitivity of HeLa cells to X-ray-induced cell death by inhibiting TrxR activities and activating downstream reactive oxygen species-mediated signaling pathways. In vivo experiments using intravenous or intratumor injection demonstrate that the Bi2Se3-CS-RGD NSs are more efficient tumor growth inhibitors compared to bare Bi2Se3 NSs. The multifunctionality of the NSs enables the use of photoacoustic imaging and magnetic resonance imaging to examine their targeting ability and therapeutic effects, respectively. In addition, the RGD-decorated Bi2Se3NSs show much better in vivo biocompatibility and can be efficiently expelled from the body after 48 h post injection. This study reveals an effective and safe theranostic agent for next-generation cancer radiotherapy.

来源: NPG Asia Materials 浏览次数:0

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