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Nat Commun:澳洲学者发现眼部存在免疫细胞

摘要 : 2017年9月29日,国际学术权威刊物自然出版集团旗下子刊《Nature Communication》杂志在线发表了澳大利亚莫纳什大学Jennifer L. Wilkinson-Berka研究员的一篇研究论文,研究发现眼部也存在免疫细胞

2017年9月29日,国际学术权威刊物自然出版集团旗下子刊《Nature Communication》杂志在线发表了澳大利亚莫纳什大学Jennifer L. Wilkinson-Berka研究员的一篇研究论文,研究发现眼部也存在免疫细胞,研究有望为早产儿视网膜病变、糖尿病视网膜病变等新生血管性视网膜病变提供新疗法。

研究人员发现具有抗病功能的免疫细胞——调节性T细胞存在于人的视网膜中。Jennifer L. Wilkinson-Berka研究员说眼睛和大脑一样有某种屏障,人们过去认为眼组织中不会有免疫细胞。她认为,这道屏障是有弱点的,可以让T细胞进入。

论文报告视网膜中的调节性T细胞可以修补受损的视网膜血管。在动物实验中,研究人员增强了调节性T细胞的活性,使早产儿视网膜病变的症状显著减轻,他们目前已经开始进行小规模临床试验。此外,验证调节性T细胞对糖尿病视网膜病变效果的动物实验也将展开。

早产儿视网膜病变常见于早产儿,是婴儿视力减退甚至失明的主要原因。该病目前主要用激光手术治疗,但激光在阻止异常血管生长的同时也会对健康细胞造成损害,治疗后病情也可能继续恶化。

原文链接:

Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis

原文摘要:

Neovascular retinopathies are major causes of vision loss; yet treatments to prevent the condition are inadequate. The role of regulatory T cells in neovascular retinopathy is unknown. Here we show that in retinopathy regulatory T cells are transiently increased in lymphoid organs and the retina, but decline when neovascularization is established. The decline is prevented following regulatory T cells expansion with an IL-2/anti-IL-2 mAb complex or the adoptive transfer of regulatory T cells. Further, both approaches reduce vasculopathy (vaso-obliteration, neovascularization, vascular leakage) and alter the activation of Tmem119+ retinal microglia. Our in vitro studies complement these findings, showing that retinal microglia co-cultured with regulatory T cells exhibit a reduction in co-stimulatory molecules and pro-inflammatory mediators that is attenuated by CTLA-4 blockade. Collectively, we demonstrate that regulatory T cells are recruited to the retina and, when expanded in number, repair the vasculature. Manipulation of regulatory T cell numbers is a previously unrecognized, and promising avenue for therapies to prevent blinding neovascular retinopathies.

来源: Nature Communications 浏览次数:0

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