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Sci.Rep:南方医科大学彭鸿娟课题组发表登革热研究论文

摘要 : 日前,自然出版集团旗下综合类刊物《Scientific Reports》在线发表了南方医科大学公共卫生与热带医学学院彭鸿娟课题组发表的论文,论文详细分析了2014年广东省登革热大爆发的特点。

 日前,自然出版集团旗下综合类刊物《Scientific Reports》在线发表了南方医科大学公共卫生与热带医学学院彭鸿娟课题组发表的论文,论文详细分析了2014年广东省登革热大爆发的特点:登革热发病人数达本省最高纪录(超过4.5万), 表现出多源头爆发及有本地流行的特点;高温、充沛的降雨、快速城市化、人口流动性、及东南亚登革大流行,均可为此次登革爆发流行的促因。

相关阅读:PNAS:南方医科大学公卫学院陈晓光研究组等发发表登革热研究论文

课题组从急性病人血清中分离出33株登革病毒,E蛋白测序及分子进化分析发现,造成爆发的病毒包括DENV-1 (基因型 I 和III) 以及DENV-2 (Cosmopolitan和Asian I 基因型);对广东省历年来造成流行的登革病毒序列的回顾性研究及分子进化分析,发现广东省内2004-2014年间DENV-1基因型I的连续报道,而基因型II 在2009-2014年间被连续报道,DENV-2 的Cosmopolitan和 Asian I 基因型则在2012-2014年间被连续报道,以上基因型可能已在广东省稳定保存下来。

2014年广东省全年累计报告本地感染登革热确诊病例占98%,输入病例仅占2%,分离到的以上DENV基因型均在近年来在本省长期存在,说明广东省已面临登革本地化的严重威胁。其他学者关于2005-2011年登革流行特点的回顾分析也发现有本地化的趋势,及2015年广东省首例登革热属广州本地DENV-I型感染,这些都进一步验证了彭鸿娟教授课题组的结论。随着新毒株的输入和本地毒株的变异演化,病毒表现出多样性和复杂性,造成今后人群中再次感染不同型别病毒导致重症登革的高风险。

原文链接:

Multiple Sources of Infection and Potential Endemic Characteristics of the Large Outbreak of Dengue in Guangdong in 2014

原文摘要:

A large outbreak of dengue, with the most documented cases, occurred in Guangdong China in 2014. Epidemiological studies and phylogenetic analysis of the isolated dengue virus (DENV) showed this outbreak was attributed to multiple sources and caused by at least two genotypes of DENV-1 (Genotypes I and III) and two genotypes of DENV-2 (Cosmopolitan and Asian I Genotypes). A retrospective review and phylogenetic analysis of DENV isolated in Guangdong showed that DENV-1 Genotype I strains were reported continuously during 2004–2014, Genotype III strains were reported during 2009–2014 ; DENV-2 Cosmopolitan and Asian I Genotype strains were reported continuously during 2012–2014. At least 45,171 cases were reported in this outbreak, with 65.9% of the patients in the 21–55-year-old group. A trend toward a decrease in the daily newly emerged cases lagged by approximately 20 days compared with the mosquito density curve. Several epidemiological characteristics of this outbreak and the stably sustained serotypes and genotypes of DENV isolated in Guangdong suggest that Guangdong has been facing a threat of transforming from a dengue epidemic area to an endemic area. The high temperature, drenching rain, rapid urbanization, and pandemic of dengue in Southeast Asia may have contributed to this large outbreak of dengue.

来源: Scientific Reports 浏览次数:0

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