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Nat Com:新疫苗提高针对肺结核的保护

标签:疫苗 肺结核
摘要 : 一种新研发的疫苗比惟一现有疫苗能更好地防止猴子患肺结核。

 一种新研发的疫苗比惟一现有疫苗能更好地防止猴子患肺结核。Nature Communications上在线发表的一篇论文显示,这一疫苗能诱发免疫系统产生强的反应,可对感染了致命剂量结核分枝杆菌(引起这种疾病的病原体)的动物提供保护。肺结核仍然是一种全球性的流行病,部分原因是当前的疫苗接种方法保护效果有限。因此迫切需要新型疫苗。

Deepak Kaushal及同事利用“改版”的结核分枝杆菌研发出一种疫苗。这种“改版”的结核分枝杆菌没有致病潜力,但却能够诱发一个特定的免疫反应。对猕猴,用这种疫苗接种(通过吸入方式用药),针对随后由高剂量的这种细菌造成的感染能提供高水平的保护,导致更强的免疫反应和降低的疾病症状。重要的是,这种保护效应要比当给实验动物接种目前针对肺结核的惟一疫苗BCG时所产生的保护效应强得多。



Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis


Tuberculosis (TB) is a global pandaemic, partially due to the failure of vaccination approaches. Novel anti-TB vaccines are therefore urgently required. Here we show that aerosol immunization of macaques with the Mtb mutant in SigH (MtbΔsigH) results in significant recruitment of inducible bronchus-associated lymphoid tissue (iBALT) as well as CD4+ and CD8+ T cells expressing activation and proliferation markers to the lungs. Further, the findings indicate that pulmonary vaccination with MtbΔsigH elicited strong central memory CD4+ and CD8+ T-cell responses in the lung. Vaccination with MtbΔsigH results in significant protection against a lethal TB challenge, as evidenced by an approximately three log reduction in bacterial burdens, significantly diminished clinical manifestations and granulomatous pathology and characterized by the presence of profound iBALT. This highly protective response is virtually absent in unvaccinated and BCG-vaccinated animals after challenge. These results suggest that future TB vaccine candidates can be developed on the basis of MtbΔsigH.

来源: Nature Communications 浏览次数:0


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