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摘要 : 近日,Nature出版集团旗下子刊《Scientific Reports》上在线发表中国科学院深圳先进技术研究院研究员蔡林涛领衔的纳米医学研究小组,在“智能纳米载药”可视化精准治疗癌症方面取得新研究成果。

 近日,Nature出版集团旗下子刊《Scientific Reports》上在线发表中国科学院深圳先进技术研究院研究员蔡林涛领衔的纳米医学研究小组,在“智能纳米载药”可视化精准治疗癌症方面取得新研究成果。

蔡林涛以团队工作为基础(ACSnano,2013,7:2056-2067;ACS nano,2014,8:12310-12322.),提出联合多种药物、以不同机制进行联合治疗的“纳米鸡尾酒疗法”,确立了癌症高效治疗和多学科综合治疗的新思路。在“智能纳米载药”可视化精准治疗癌症的研究工作中,蔡林涛团队成员赵鹏飞、郑明彬采用温度敏感的磷脂共包载化疗药物阿霉素和光敏剂吲哚菁绿,构建了肿瘤可视化精准联合治疗的温敏智能纳米载药体系。该体系显著提高了药物的稳定性和肿瘤部位的富集,避免了药物在体内的快速代谢。近红外荧光能够实时监控阿霉素和吲哚菁绿在肿瘤部位的富集与代谢,在荧光图像的引导下,近红外激光激发,局部温度升高“开启”温敏纳米体系,精确控制化疗药物的释放和肿瘤部位的局部温度,通过精准化学-光热联合治疗手段根治肿瘤,实现了癌症可视化精准治疗。




NIR-driven Smart Theranostic Nanomedicine for On-demand Drug Release and Synergistic Antitumour Therapy


Smart nanoparticles (NPs) that respond to external and internal stimulations have been developing to achieve optimal drug release in tumour. However, applying these smart NPs to attain high antitumour performance is hampered by limited drug carriers and inefficient spatiotemporal control. Here we report a noninvasive NIR-driven, temperature-sensitive DI-TSL (DOX/ICG-loaded temperature sensitive liposomes) co-encapsulating doxorubicin (DOX) and indocyanine green (ICG). This theranostic system applies thermo-responsive lipid to controllably release drug, utilizes the fluorescence (FL) of DOX/ICG to real-time trace the distribution of NPs, and employs DOX/ICG to treat cancer by chemo/photothermal therapy. DI-TSL exhibits uniform size distribution, excellent FL/size stability, enhanced response to NIR-laser, and 3 times increased drug release through laser irradiation. After endocytosis by MCF-7 breast adenocarcinoma cells, DI-TSL in cellular endosomes can cause hyperthermia through laser irradiation, then endosomes are disrupted and DI-TSL ‘opens’ to release DOX simultaneously for increased cytotoxicity. Furthermore, DI-TSL shows laser-controlled release of DOX in tumour, enhanced ICG and DOX retention by 7 times and 4 times compared with free drugs. Thermo-sensitive DI-TSL manifests high efficiency to promote cell apoptosis, and completely eradicate tumour without side-effect. DI-TSL may provide a smart strategy to release drugs on demand for combinatorial cancer therapy.

来源: Scientific Reports 浏览次数:0


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