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Nature:免疫系统的生物钟

摘要 : 在植物中和在很多其他真核生物中,生物钟不仅通过影响基因转录、而且通过改变生物的氧化还原状态来确保生物过程每天的有节奏波动。

 在植物中和在很多其他真核生物中,生物钟不仅通过影响基因转录、而且通过改变生物的氧化还原状态来确保生物过程每天的有节奏波动。氧化还原节奏与生物钟相联系的分子机制以及氧化还原-生物节律相互作用的生物学意义仍不清楚。Xinnian Dong及同事识别出了拟南芥的这种氧化还原节奏的一个出乎意料的调控因子。他们发现,“主免疫调控因子”NPR1独立于病原感染来感应一个植株的氧化还原状态和调控早上及晚上的核心生物钟基因的转录。这个网络架构帮助植物“门控”它们对早上的免疫反应,从而减小对生长(发生在晚上)的影响。

原文链接:

Redox rhythm reinforces the circadian clock to gate immune response

原文摘要:

Recent studies have shown that in addition to the transcriptional circadian clock, many organisms, including Arabidopsis, have a circadian redox rhythm driven by the organism’s metabolic activities. It has been hypothesized that the redox rhythm is linked to the circadian clock, but the mechanism and the biological significance of this link have only begun to be investigated. Here we report that the master immune regulator NPR1 (non-expressor of pathogenesis-related gene 1) of Arabidopsis is a sensor of the plant’s redox state and regulates transcription of core circadian clock genes even in the absence of pathogen challenge. Surprisingly, acute perturbation in the redox status triggered by the immune signal salicylic acid does not compromise the circadian clock but rather leads to its reinforcement. Mathematical modelling and subsequent experiments show that NPR1 reinforces the circadian clock without changing the period by regulating both the morning and the evening clock genes. This balanced network architecture helps plants gate their immune responses towards the morning and minimize costs on growth at night. Our study demonstrates how a sensitive redox rhythm interacts with a robust circadian clock to ensure proper responsiveness to environmental stimuli without compromising fitness of the organism.

来源: Nature 浏览次数:0

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