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Nature: 中国的H7N9流感病毒

标签:H7N9 病毒 中国
摘要 : Yi Guan及同事对H7N9流感病毒2013年第二轮爆发期间的演变和传播情况进行了追踪。他们提供了来自从2013年10月到2014年7月在中国全国范围内所进行的流感监测期间收集到的分离毒株的大量新的H7N9病毒序列。


Yi Guan及同事对H7N9流感病毒2013年第二轮爆发期间的演变和传播情况进行了追踪。他们提供了来自从2013年10月到2014年7月在中国全国范围内所进行的流感监测期间收集到的分离毒株的大量新的H7N9病毒序列。他们发现,该病毒已分化成截然不同的分支,已在鸡身上安营扎寨,并且已经传播到了更大的地域范围。H7N9病毒在中国流感生态系统中扎根的方式强烈显示,这种病毒应当作为有可能对人类造成疫情的一个首要病毒种类加以考虑。


Dissemination, divergence and establishment of H7N9 influenza viruses in China


since 2013 the occurrence of human infections by a novel avian H7N9 influenza virus in China has demonstrated the continuing threat posed by zoonotic pathogens. Although the first outbreak wave that was centred on eastern China was seemingly averted, human infections recurred in October 2013 . It is unclear how the H7N9 virus re-emerged and how it will develop further; potentially it may become a long-term threat to public health. Here we show that H7N9 viruses have spread from eastern to southern China and become persistent in chickens, which has led to the establishment of multiple regionally distinct lineages with different reassortant genotypes. Repeated introductions of viruses from Zhejiang to other provinces and the presence of H7N9 viruses at live poultry markets have fuelled the recurrence of human infections. This rapid expansion of the geographical distribution and genetic diversity of the H7N9 viruses poses a direct challenge to current disease control systems. Our results also suggest that H7N9 viruses have become enzootic in China and may spread beyond the region, following the pattern previously observed with H5N1 and H9N2 influenza viruses.

来源: Nature 浏览次数:0


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