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Nature Immunology:负责处理死亡细胞的两种受体

摘要 : 美国索尔克生物研究所和英国爱丁堡大学合作,在新研究中介绍了免疫系统处理死细胞的不同方法。相关文章发表于2014年9月7日的《Nature Immunology》杂志上。
模型显示Axl和Mer在抗炎和耐受性环境中的调节和作用的差异

模型显示Axl和Mer在抗炎和耐受性环境中的调节和作用的差异

人体内每天有数十亿死细胞产生,而死细胞的累积会引发组织异常。因而扮演细胞垃圾收集者的特定细胞就很有存在的必要。

Greg Lemke等人发现,在死细胞收集清除过程中,免疫细胞会使用到不同的细胞受体,这些细胞受体被统称为TAM受体酪氨酸激酶。而TAM受体——Mer和Axl能识别依附在死细胞表面的蛋白并标记下来以便后续处理。Mer大多在正常情况下运行,通过移除死细胞来保持组织的免疫耐受性。而相反的是,Axl在发炎时会数量激增并将移除过程接管过来。

随着目前针对TAM受体的临床治疗方法在癌症和自动免疫类疾病方向的发展,Mer和Axl功能上的区分变得很重要。

原文摘要:

Diversification of TAM receptor tyrosine kinase function

Anna Zagórska, Paqui G Través, Erin D Lew, Ian Dransfield & Greg Lemke

The clearance of apoptotic cells is critical for both tissue homeostasis and the resolution of inflammation. We found that the TAM receptor tyrosine kinases Axl and Mer had distinct roles as phagocytic receptors in these two settings, in which they exhibited divergent expression, regulation and activity. Mer acted as a tolerogenic receptor in resting macrophages and during immunosuppression. In contrast, Axl was an inflammatory response receptor whose expression was induced by proinflammatory stimuli. Axl and Mer differed in their ligand specificities, ligand-receptor complex formation in tissues, and receptor shedding upon activation. These differences notwithstanding, phagocytosis by either protein was strictly dependent on receptor activation triggered by bridging of TAM receptor–ligand complexes to the 'eat-me' signal phosphatidylserine on the surface of apoptotic cells.

来源: 中国科学报 浏览次数:243

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