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Nature子刊:中科院动物所段恩奎研究组等发表精子小RNA综述论文

摘要 : 2016年10月3日,国际学术权威刊物自然出版集团旗下子刊《Nature Reviews Genetics》杂志在线发表了中国科学院动物研究所段恩奎研究员及美国内华达大学的合作者陈琦、闫威题为Epigenetic inheritance of acquired traits via sperm RNAs and sperm RNA modifications 的综述论文。

 2016年10月3日,国际学术权威刊物自然出版集团旗下子刊《Nature Reviews Genetics》杂志在线发表了中国科学院动物研究所段恩奎研究员及美国内华达大学的合作者陈琦、闫威题为Epigenetic inheritance of acquired traits via sperm RNAs and sperm RNA modifications 的综述论文。

文章对近年来逐步升温的精子小RNA(miRNAs, tsRNAs等)研究及其介导的父系获得性性状的跨代遗传现象进行了系统的总结,并结合该领域悠久的发展历史(拉马克进化论、达尔文泛生论、魏斯曼屏障等),对未来尚需解决的关键科学问题和技术问题进行了展望。

精子RNA作为信息载体将父代获得性性状传递给子代

原文链接:

Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications

原文摘要:

once deemed heretical, emerging evidence now supports the notion that the inheritance of acquired characteristics can occur through ancestral exposures or experiences and that certain paternally acquired traits can be 'memorized' in the sperm as epigenetic information. The search for epigenetic factors in mammalian sperm that transmit acquired phenotypes has recently focused on RNAs and, more recently, RNA modifications. Here, we review insights that have been gained from studying sperm RNAs and RNA modifications, and their roles in influencing offspring phenotypes. We discuss the possible mechanisms by which sperm become acquisitive following environmental–somatic–germline interactions, and how they transmit paternally acquired phenotypes by shaping early embryonic development.

来源: Nature Reviews Genetics 浏览次数:0

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