DOI：10.1038/nature17164 作者：William Davidson
摘要 : William Davidson及同事报告了对大西洋鲑鱼基因组所做的测序和组装，他们还发现其基因组可作为一个有用参照，来改进其他鲑科鱼的基因组组装。
William Davidson及同事报告了对大西洋鲑鱼基因组所做的测序和组装，他们还发现其基因组可作为一个有用参照，来改进其他鲑科鱼的基因组组装。他们的分析提供了对在这个分支中所发生的两轮全基因组复制之间的重复保留模式 (duplicate retention patterns)的认知。
The whole-genome duplication 80 million years ago of the common ancestor of salmonids (salmonid-specific fourth vertebrate whole-genome duplication, Ss4R) provides unique opportunities to learn about the evolutionary fate of a duplicated vertebrate genome in 70 extant lineages. Here we present a high-quality genome assembly for Atlantic salmon (Salmo salar), and show that large genomic reorganizations, coinciding with bursts of transposon-mediated repeat expansions, were crucial for the post-Ss4R rediploidization process. Comparisons of duplicate gene expression patterns across a wide range of tissues with orthologous genes from a pre-Ss4R outgroup unexpectedly demonstrate far more instances of neofunctionalization than subfunctionalization. Surprisingly, we find that genes that were retained as duplicates after the teleost-specific whole-genome duplication 320 million years ago were not more likely to be retained after the Ss4R, and that the duplicate retention was not influenced to a great extent by the nature of the predicted protein interactions of the gene products. Finally, we demonstrate that the Atlantic salmon assembly can serve as a reference sequence for the study of other salmonids for a range of purposes.
来源： Nature 浏览次数：1