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Nature:单体型分辨率的表观基因组图

摘要 : 作为 “表观基因组路线图”项目的一部分,Bing Ren及同事采用一个跨染色体单体型重建策略来构建多种不同人体组织的单体型分辨率的表观基因组图。

 作为 “表观基因组路线图”项目的一部分,Bing Ren及同事采用一个跨染色体单体型重建策略来构建多种不同人体组织的单体型分辨率的表观基因组图。

这些图件显示了染色质状态和转录方面所存在的广泛的等位基因偏差,这些偏差在不同组织之间以及不同个体之间都有所不同。

作者还对基因与它们控制序列之间的顺式调控关系以及重复序列受组织限定的活性进行了研究。

nature14217-f1

原文链接:

Integrative analysis of haplotype-resolved epigenomes across human tissues

Allelic differences between the two homologous chromosomes can affect the propensity of inheritance in humans; however, the extent of such differences in the human genome has yet to be fully explored. Here we delineate allelic chromatin modifications and transcriptomes among a broad set of human tissues, enabled by a chromosome-spanning haplotype reconstruction strategy1. The resulting large collection of haplotype-resolved epigenomic maps reveals extensive allelic biases in both chromatin state and transcription, which show considerable variation across tissues and between individuals, and allow us to investigate cis-regulatory relationships between genes and their control sequences. Analyses of histone modification maps also uncover intriguing characteristics of cis-regulatory elements and tissue-restricted activities of repetitive elements. The rich data sets described here will enhance our understanding of the mechanisms by which cis-regulatory elements control gene expression programs.

doi:10.1038/nature14217

Epigenomics: Roadmap for regulation

doi:10.1038/518314a

对应Nature杂志: 2015年02月19日Nature杂志精选

来源: Nature 浏览次数:40

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