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Nature:造成肥胖的遗传因素

摘要 : 在本期发表的来自GIANT Consortium的两篇论文的第二篇当中,Elizabeth Speliotes 及同事对体重指数(BMI,常用来定义肥胖症和肥胖倾向)做了一项全基因组关联研究和Metabochip元分析,发现了97个与BMI相关的位点,其中56个是新的。

 

在本期发表的来自GIANT Consortium的两篇论文的第二篇当中,Elizabeth Speliotes 及同事对体重指数(BMI,常用来定义肥胖症和肥胖倾向)做了一项全基因组关联研究和metabochip元分析,发现了97个与BMI相关的位点,其中56个是新的。

这些位点中很多都对其他代谢表现型有显著影响。这97个位点占BMI变异的大约2.7%,同时在全基因组范围内所做估计表明,常见变异占BMI变异的20%以上。

通道分析(Pathway analyses)表明中枢神经系统与肥胖易感性有关,其中包括突触功能、谷氨酸信号传导、胰岛素分泌/作用、能量代谢、脂肪生物学和脂肪生成等。

原文链接:Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10−8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ~2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

对应Nature杂志: 2015年02月12日Nature杂志精选

来源: Nature 浏览次数:268

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