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Nature:牙齿发育随时间发生的变化

摘要 : 芬兰赫尔辛基大学等处的一个国际研究组建立了一个关于牙齿发育的计算模型,该模型有一个界面 (ToothMaker),它为弄清物种之间的关系提供了一个新工具。相关文章发表于2014年7月30日的《Nature》杂志上。
Nature:牙齿发育随时间发生的变化

演化传统上呈现为一系列成年形态,反映它们随时间所发生的变化,而牙齿则经常是古生物学家可以利用的最好(或惟一)证据。牙齿特征因此被广泛用来确定化石物种的相关性。

现在, Jukka Jernvall及同事采用发育生物学方法来重现啮齿类动物牙齿过去5000万年的演化。不能产生形态发生素“外异蛋白”的小鼠有非常一般化的牙齿。向突变牙齿外植体中添加少量“外异蛋白”,会重现啮齿类动物牙齿的形态随时间推移已知所发生的变化。

作者建立了一个关于牙齿发育的计算模型,该模型有一个界面 (ToothMaker),它为弄清物种之间的关系提供了一个新工具。

原文摘要:

Replaying evolutionary transitions from the dental fossil record

Enni Harjunmaa, Kerstin Seidel, Teemu Häkkinen, Elodie Renvoisé, Ian J. Corfe, Aki Kallonen, Zhao-Qun Zhang, Alistair R. Evans, Marja L. Mikkola, Isaac Salazar-Ciudad, Ophir D. Klein & Jukka Jernvall

The evolutionary relationships of extinct species are ascertained primarily through the analysis of morphological characters. Character inter-dependencies can have a substantial effect on evolutionary interpretations, but the developmental underpinnings of character inter-dependence remain obscure because experiments frequently do not provide detailed resolution of morphological characters. Here we show experimentally and computationally how gradual modification of development differentially affects characters in the mouse dentition. We found that intermediate phenotypes could be produced by gradually adding ectodysplasin A (EDA) protein in culture to tooth explants carrying a null mutation in the tooth-patterning gene Eda. By identifying development-based character inter-dependencies, we show how to predict morphological patterns of teeth among mammalian species. Finally, in vivo inhibition of sonic hedgehog signalling in Edanull teeth enabled us to reproduce characters deep in the rodent ancestry. Taken together, evolutionarily informative transitions can be experimentally reproduced, thereby providing development-based expectations for character-state transitions used in evolutionary studies.

对应Nature杂志: 2014年8月7日Nature杂志精选

来源: Nature 浏览次数:138

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