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Nature封面故事:英国的人口史

摘要 : 遗传数据已被广泛用来帮助我们了解人口历史和迁移。现在,随着 “单核苷酸多态性”(SNP)数据(它们对个体之间的基因组序列中单一位置的差异进行编目)全基因组分析方法的问世,人口之间精细尺度的遗传变异可以被用作历史上人口统计事件的一个特征。

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 遗传数据已被广泛用来帮助我们了解人口历史和迁移。现在,随着 “单核苷酸多态性”(SNP)数据(它们对个体之间的基因组序列中单一位置的差异进行编目)全基因组分析方法的问世,人口之间精细尺度的遗传变异可以被用作历史上人口统计事件的一个特征。

Peter Donnelly及同事利用来自一个在地理分布上非常多元化的人口样本(该样本由来自英国的2000多人组成)的这种数据,显示了基因群与地域之间的显著一致性。这些结果为了解英国人口的几个方面提供了新线索。例如,盎格鲁-撒克逊移民对英格兰东南的遗传贡献不到一半,说明在罗马时代之前、但在中石器时代之后存在着来自欧洲大陆的显著人口流动。这些数据还显示,非撒克逊地区包含在遗传上有差异的子人群,而不是一个统一的 “凯尔特”人群。

原文链接:The fine-scale genetic structure of the British population

Fine-scale genetic variation between human populations is interesting as a signature of historical demographic events and because of its potential for confounding disease studies. We use haplotype-based statistical methods to analyse genome-wide single nucleotide polymorphism (SNP) data from a carefully chosen geographically diverse sample of 2,039 individuals from the United Kingdom. This reveals a rich and detailed pattern of genetic differentiation with remarkable concordance between genetic clusters and geography. The regional genetic differentiation and differing patterns of shared ancestry with 6,209 individuals from across Europe carry clear signals of historical demographic events. We estimate the genetic contribution to southeastern England from Anglo-Saxon migrations to be under half, and identify the regions not carrying genetic material from these migrations. We suggest significant pre-Roman but post-Mesolithic movement into southeastern England from continental Europe, and show that in non-Saxon parts of the United Kingdom, there exist genetically differentiated subgroups rather than a general ‘Celtic’ population.

对应Nature杂志: 2015年03月19日Nature杂志精选

来源: Nature 浏览次数:77

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