nature

当前位置: Nature » 细胞生物学 » 正文

Nat Commun:英国学者报道子宫年龄影响小鼠受孕成功率

摘要 : 2017年9月4日,国际学术权威刊物自然出版集团旗下子刊《Nature Communication》杂志在线发表了英国剑桥大学Myriam Hemberger研究组的一篇研究论文,研究论文报道子宫的年龄能够影响小鼠的胚胎移植和受孕成功率。

2017年9月4日,国际学术权威刊物自然出版集团旗下子刊《Nature Communication》杂志在线发表了英国剑桥大学Myriam Hemberger研究组的一篇研究论文,研究论文报道子宫的年龄能够影响小鼠的胚胎移植和受孕成功率。此前的研究一直重点关注卵细胞缺陷如何导致与年龄相关的妊娠并发症,但新发现强调了母体环境也是引起妊娠并发症的一个重要因素。

已知孕妇高龄是增加繁殖风险的一个重要因素,卵细胞的老龄问题会导致胚胎中染色体缺陷,并进一步引发早期妊娠丢失。Myriam Hemberger及同事通过研究小鼠,提出妊娠晚期出现妊娠并发症(比如流产和围产期死亡)的可能原因。他们观察到随着小鼠母体年龄增长,胎儿健康和存活率下降。出现的健康问题包括发育迟缓和心脏缺陷,它们与子宫中为胚胎提供养分的胎盘的缺陷有关。作者表明这些问题可以通过将胚胎从年老的母体转移到年轻的受体中加以解决。实验暗示子宫供养胎盘和胚胎的能力随着年龄增长而下降。子宫衰老与蜕膜中免疫细胞的数量减少有关。蜕膜是子宫中的结构,与胎盘共同支持胚胎的成长发育。作者还发现随着年龄增加,子宫内的细胞对刺激蜕膜形成的荷尔蒙响应减少。

研究结果强调小鼠中母体的年龄可能影响胚胎存活——不只是因为卵细胞年龄,还有子宫年龄,从而为胚胎的健康和存活提供更多信息支持。作者强调,该研究仅限于小鼠,目前并无证据证明该机制存在于人类。

原文链接:

Decidualisation and placentation defects are a major cause of age-related reproductive decline

原文摘要:

Mammalian reproductive performance declines rapidly with advanced maternal age. This effect is largely attributed to the exponential increase in chromosome segregation errors in the oocyte with age. Yet many pregnancy complications and birth defects that become more frequent in older mothers, in both humans and mice, occur in the absence of karyotypic abnormalities. Here, we report that abnormal embryonic development in aged female mice is associated with severe placentation defects, which result from major deficits in the decidualisation response of the uterine stroma. This problem is rooted in a blunted hormonal responsiveness of the ageing uterus. importantly, a young uterine environment can restore normal placental as well as embryonic development. Our data highlight the pivotal, albeit under-appreciated, impact of maternal age on uterine adaptability to pregnancy as major contributor to the decline in reproductive success in older females.

来源: Nature Communications 浏览次数:1

热门文章TOP

RSS订阅 - 填写您的邮件地址,订阅我们的精彩内容: - 网站地图
网站联系电话:020-87540820 备案号:粤ICP备11050685号-8 增值电信业务经营许可证:粤B2-20120479
©2011-2015 生物帮 All rights reserved.