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Nature子刊:中科院广州生物院陈凌研究组发表腺病毒流行病学研究进展

摘要 : 2017年6月7日,国际学术权威刊物自然出版集团旗下子刊《Emerging Microbes & Infections》杂志在线发表了中国科学院广州生物医药与健康研究院陈凌研究组与广州市血液中心、广州市妇女儿童医疗中心合作的一篇研究论文,论文报道了研究组在腺病毒流行病学研究新进展。

2017年6月7日,国际学术权威刊物自然出版集团旗下子刊《Emerging Microbes & Infections》杂志在线发表了中国科学院广州生物医药与健康研究院陈凌研究组与广州市血液中心、广州市妇女儿童医疗中心合作的一篇研究论文,论文报道了研究组在腺病毒流行病学研究新进展。

腺病毒是常见的呼吸道病原体,在健康成人中常引起自限性疾病,如普通感冒、流行性角膜结膜炎、肠胃炎等,而在婴幼儿、免疫力低下人群以及聚居人群中可导致社区获得性肺炎。近年来,新型腺病毒14型(Ad14)和55型(Ad55)在美国、欧洲以及我国时有爆发,具有较强的致病力,可引起重症肺炎甚至死亡。目前Ad14和Ad55已受到全球公共卫生系统的广泛关注。但是,Ad14和Ad55在我国健康人群中的既往流行状况以及群体免疫水平尚不清楚。

该研究中,研究人员率先制备了携带分泌型碱性磷酸酯酶的Ad14和Ad55报告病毒,建立了血清中和抗体的快速检测平台,检测了我国南方地区健康成人血清中和抗体阳性率。研究发现,这两种病毒在我国已有一定流行,但我国成人群体免疫水平较低。研究还发现,Ad55感染诱导较强的中和抗体反应,中和抗体阳性率及抗体滴度与血型有关,而与性别关系不大。该研究初步阐明Ad14、Ad55在我国健康人群的既往流行状况以及群体免疫水平,提示在我国人群爆发流行的可能性,并为下一步研究Ad14、Ad55与人体免疫系统的相互作用奠定基础。

原文链接:

Seroprevalence of neutralizing antibodies against adenovirus type 14 and 55 in healthy adults in Southern China

原文摘要:

Re-emerging human adenovirus types 14 (Ad14) and 55 (Ad55) have caused severe respiratory diseases and even deaths during recent outbreaks. However, the seroprevalence of neutralizing antibodies (nAbs) in healthy adults, which may reflect previous circulation and help to predict potential outbreaks, remains unclear. In this study, we established micro-neutralizing (MN) assays on the basis of recombinant Ad14 and Ad55 reporter viruses, and we investigated serum nAbs in healthy blood donors from Southern China. We found that the overall seropositive rates were 24.8% and 22.4% for Ad14 and Ad55 nAbs, respectively. The seropositive rates were low in individuals younger than 20, and they gradually increased with age. Ad55-seropositive individuals tended to have high nAb titers (>1000), while low (72–200) and moderate (201–1000) nAb levels were frequently observed in Ad14-seropositive ones. Surprisingly, the seropositive rates and nAb levels were associated with the blood type but not the gender of the blood donors, with type AB individuals displaying higher seropositive rates and nAb levels. Interestingly, a significant positive correlation was observed between Ad14 and Ad55 seroprevalence, and higher titers of nAbs were detected in double-positive individuals compared to single-positive ones. These results clarified the human humoral immune responses against Ad14 and Ad55 and revealed a low level of herd immunity in some subpopulations, which emphasized the importance of monitoring these two highly virulent adenoviruses and reinforced the development of prophylactic vaccines.

来源: Emerging Microbes & Infections 浏览次数:0

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