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摘要 : 发育因素和荷尔蒙因素是生理性别差异的已知贡献因素。


发育因素和荷尔蒙因素是生理性别差异的已知贡献因素。Irene Miguel-Aliaga及同事描述了在果蝇小肠的成体干细胞中发挥作用、主管在器官大小、生殖过程中的可塑性以及对致瘤性损伤的反应这几个方面的性别差异的一个以前没有被识别出的性别分化通道。这一发现表明,成年小肠干细胞的内在性别身份在成年生活中(包括在维持器官大小方面和调制其可塑性方面)会起一个关键作用。


The sexual identity of adult intestinal stem cells controls organ size and plasticity


Sex differences in physiology and disease susceptibility are commonly attributed to developmental and/or hormonal factors, but there is increasing realization that cell-intrinsic mechanisms play important and persistent roles. Here we use the Drosophila melanogaster intestine to investigate the nature and importance of cellular sex in an adult somatic organ in vivo. We find that the adult intestinal epithelium is a cellular mosaic of different sex differentiation pathways, and displays extensive sex differences in expression of genes with roles in growth and metabolism. Cell-specific reversals of the sexual identity of adult intestinal stem cells uncovers the key role this identity has in controlling organ size, reproductive plasticity and response to genetically induced tumours. Unlike previous examples of sexually dimorphic somatic stem cell activity, the sex differences in intestinal stem cell behaviour arise from intrinsic mechanisms that control cell cycle duration and involve a new doublesex- and fruitless-independent branch of the sex differentiation pathway downstream of transformer. Together, our findings indicate that the plasticity of an adult somatic organ is reversibly controlled by its sexual identity, imparted by a new mechanism that may be active in more tissues than previously recognized.

来源: Nature 浏览次数:0


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