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Nat Com:原始细胞模型也许可预测原始细胞周期

摘要 : Nature出版集团旗下子刊《Nature Communications》杂志上发表的一项研究报告说,在实验室生成的人造细胞也许可解释原始活细胞第一次是怎样形成复制能力的。

 Nature出版集团旗下子刊《Nature Communications》杂志上发表的一项研究报告说,在实验室生成的人造细胞也许可解释原始活细胞第一次是怎样形成复制能力的。


Tadashi Sugawara及同事通过建立一个简单的方法来将新分裂的人造细胞与其他模仿细胞的类脂球融合的办法对这一复制特性进行了模拟。这为新形成的人造细胞提供了重启这一过程所需的全部蛋白质、类脂和DNA,从而在一个实验室人工环境中创建了一个细胞周期模型。



A recursive vesicle-based model protocell with a primitive model cell cycle


Self-organized lipid structures (protocells) have been proposed as an intermediate between nonliving material and cellular life. Synthetic production of model protocells can demonstrate the potential processes by which living cells first arose. While we have previously described a giant vesicle (GV)-based model protocell in which amplification of DNA was linked to self-reproduction, the ability of a protocell to recursively self-proliferate for multiple generations has not been demonstrated. Here we show that newborn daughter GVs can be restored to the status of their parental GVs by pH-induced vesicular fusion of daughter GVs with conveyer GVs filled with depleted substrates. We describe a primitive model cell cycle comprising four discrete phases (ingestion, replication, maturity and division), each of which is selectively activated by a specific external stimulus. The production of recursive self-proliferating model protocells represents a step towards eventual production of model protocells that are able to mimic evolution.

来源: Nature Communications 浏览次数:0


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