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Nature:植物对信号的分辨

摘要 : 气孔是植物表面上的小孔,它们调节植物与大气之间的水分和气体交换。植物表皮层中的气孔模式取决于通过位置信息进行的细胞-细胞通信,在这些信息当中有一类分泌的肽,被称为 “表皮模式形成因子”(EPFs)。

 

气孔是植物表面上的小孔,它们调节植物与大气之间的水分和气体交换。植物表皮层中的气孔模式取决于通过位置信息进行的细胞-细胞通信,在这些信息当中有一类分泌的肽,被称为 “表皮模式形成因子”(EPFs)。Keiko Torii 及同事通过研究气孔发育和模式形成的分子机制,发现了一个出乎意料的信号传导机制。他们发现,两种信号传导肽,即Stomagen (气孔发育的一个正调控因子)和EPF2 (这一过程的一个负调控因子),利用同一受体激酶ERECTA来微调气孔发育。有趣的是,这两种肽都以相似的亲和性与ERECTA及其共受体TMM结合,所以它们为了和受体结合而相互竞争。似乎决定被激活的ERECTA是传递一个刺激信号还是传递一个抑制信号的是下游的信号作用:活体数据显示,触发下游信号作用成分的磷酸化的是EPF2而不是Stomagen。

原文链接:

Competitive binding of antagonistic peptides fine-tunes stomatal patterning

原文摘要:

During development, cells interpret complex and often conflicting signals to make optimal decisions. Plant stomata, the cellular interface between a plant and the atmosphere, develop according to positional cues, which include a family of secreted peptides called epidermal patterning factors (EPFs). How these signalling peptides orchestrate pattern formation at a molecular level remains unclear. Here we report in Arabidopsis that Stomagen (also called EPF-LIKE9) peptide, which promotes stomatal development, requires ERECTA (ER)-family receptor kinases and interferes with the inhibition of stomatal development by the EPIDERMAL PATTERNING FACTOR 2 (EPF2)–ER module. Both EPF2 and Stomagen directly bind to ER and its co-receptor TOO MANY MOUTHS. Stomagen peptide competitively replaced EPF2 binding to ER. Furthermore, application of EPF2, but not Stomagen, elicited rapid phosphorylation of downstream signalling components in vivo. Our findings demonstrate how a plant receptor agonist and antagonist define inhibitory and inductive cues to fine-tune tissue patterning on the plant epidermis.

来源: Nature 浏览次数:0

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