当前位置: Nature » 细胞生物学 » 正文


摘要 : 三月九日,中山大学贺雄雷(Xionglei He)教授领导研究团队在Nature Communications杂志上发表文章指出,癌症发生过程中存在从多细胞性向单细胞性的逆向进化。

 三月九日,中山大学贺雄雷(Xionglei He)教授领导研究团队在Nature Communications杂志上发表文章指出,癌症发生过程中存在从多细胞性向单细胞性的逆向进化。




原文链接:The reverse evolution from multicellularity to unicellularity during carcinogenesis

Theoretical reasoning suggests that cancer may result from a knockdown of the genetic constraints that evolved for the maintenance of metazoan multicellularity. By characterizing the whole-life history of a xenograft tumour, here we show that metastasis is driven by positive selection for general loss-of-function mutations on multicellularity-related genes. expression analyses reveal mainly downregulation of multicellularity-related genes and an evolving expression profile towards that of embryonic stem cells, the cell type resembling unicellular life in its capacity of unlimited clonal proliferation. Also, the emergence of metazoan multicellularity ~600 Myr ago is accompanied by an elevated birth rate of cancer genes, and there are more loss-of-function tumour suppressors than activated oncogenes in a typical tumour. These data collectively suggest that cancer represents a loss-of-function-driven reverse evolution back to the unicellular ‘ground state’. This cancer evolution model may account for inter-/intratumoural genetic heterogeneity, could explain distant-organ metastases and hold implications for cancer therapy.

来源: Nature Communications 浏览次数:99


RSS订阅 - 填写您的邮件地址,订阅我们的精彩内容: - 网站地图
网站联系电话:020-87540820 备案号:粤ICP备11050685号-8 增值电信业务经营许可证:粤B2-20120479
©2011-2015 生物帮 All rights reserved.