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Nature:Toll-受体在身体模式形成中所起作用

标签:Toll-受体
摘要 : 沿头部到尾部轴线的身体伸长在动物发育过程中是必不可少的。对果蝇来说,伸长的空间提示是由基因的模式化表达提供的。空间提示怎样引导伸长所需的细胞重排一直不知道。这项研究识别出三个细胞表面Toll-家族受体,它们成条状沿头部到尾部的轴线表达,调控细胞的收缩特性,以产生导致组织伸长的极化重排。

nature13953-f1 

沿头部到尾部轴线的身体伸长在动物发育过程中是必不可少的。对果蝇来说,伸长的空间提示是由基因的模式化表达提供的。空间提示怎样引导伸长所需的细胞重排一直不知道。这项研究识别出三个细胞表面Toll-家族受体,它们成条状沿头部到尾部的轴线表达,调控细胞的收缩特性,以产生导致组织伸长的极化重排。

原文摘要:

A positional Toll receptor code directs convergent extension in Drosophila

Adam C. Paré, Athea Vichas, Christopher T. Fincher, Zachary Mirman, Dene L. Farrell,Avantika Mainieri & Jennifer A. Zallen

Abstract: Elongation of the head-to-tail body axis by convergent extension is a conserved developmental process throughout metazoans. In Drosophila, patterns of transcription factor expression provide spatial cues that induce systematically oriented cell movements and promote tissue elongation. However, the mechanisms by which patterned transcriptional inputs control cell polarity and behaviour have long been elusive. We demonstrate that three Toll family receptors, Toll-2, Toll-6 and Toll-8, are expressed in overlapping transverse stripes along the anterior–posterior axis and act in combination to direct planar polarity and polarized cell rearrangements during convergent extension. Simultaneous disruption of all three receptors strongly reduces actomyosin-driven junctional remodelling and axis elongation, and an ectopic stripe of Toll receptor expression is sufficient to induce planar polarized actomyosin contractility. These results demonstrate that tissue-level patterns of Toll receptor expression provide spatial signals that link positional information from the anterior–posterior patterning system to the essential cell behaviours that drive convergent extension.(doi:10.1038/nature13953 & doi: 10.1038/nature13937

对应Nature杂志: 2014年11月27日Nature杂志精选

来源: Nature中文 浏览次数:87

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