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Sci.Rep:移动的镰状细胞测试仪

摘要 : 2015年10月22日,自然出版集团旗下期刊《Scientific Reports》上发表一篇论文介绍一种可以安装在智能手机上的插件和配套的应用程序(app),可以用来诊断镰状细胞贫血。

 2015年10月22日,自然出版集团旗下期刊《Scientific Reports》上发表一篇论文介绍一种可以安装在智能手机上的插件和配套的应用程序(app),可以用来诊断镰状细胞贫血。

镰状细胞贫血是一种遗传性疾病,由引起红细胞中血红蛋白异常的突变造成。这种疾病影响着中非和西非大约25%的人口,会抑制血液流动,带来疼痛,器官损伤和更高的中风风险。然而,确认这种疾病的检测往往较为昂贵,需要专门的设备和培训。

Savas Tasoglu和他的研究团队开发了一种轻便且紧凑的3D打印插件,可以安装在智能手机上,名为镰状细胞测试仪。使用一种磁悬浮技术,这个测试仪使用一个光学透镜和智能手机的镜头来分析样本中的红细胞。接下来订制开发的应用程序会自动分析红细胞的分布来确认样本是否存在镰状细胞贫血症。

研究者指出参与测试仪的验证研究的人员由临床诊断为镰状细胞贫血症的患者和对照组组成。这项研究没有包括镰状细胞贫血症基因携带者(只携带一份突变)。需要进一步的研究来确定这个磁悬浮平台是否可以区分出来自患有镰状细胞贫血症的患者和镰状细胞贫血症基因携带者。

原文链接:

Sickle cell detection using a smartphone

原文摘要:

Sickle cell disease affects 25% of people living in Central and West Africa and, if left undiagnosed, can cause life threatening “silent” strokes and lifelong damage. However, ubiquitous testing procedures have yet to be implemented in these areas, necessitating a simple, rapid, and accurate testing platform to diagnose sickle cell disease. Here, we present a label-free, sensitive, and specific testing platform using only a small blood sample (<1 μl) based on the higher density of sickle red blood cells under deoxygenated conditions. Testing is performed with a lightweight and compact 3D-printed attachment installed on a commercial smartphone. This attachment includes an LED to illuminate the sample, an optical lens to magnify the image, and two permanent magnets for magnetic levitation of red blood cells. The sample is suspended in a paramagnetic medium with sodium metabisulfite and loaded in a microcapillary tube that is inserted between the magnets. Red blood cells are levitated in the magnetic field based on equilibrium between the magnetic and buoyancy forces acting on the cells. Using this approach, we were able to distinguish between the levitation patterns of sickle versus control red blood cells based on their degree of confinement.

来源: Scientific Reports 浏览次数:0

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