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Nat Com:胆汁酸介导胃旁路减肥手术

摘要 : 本期Nature Communications上发表的一项研究报告说,将小鼠的胆汁向小肠的最后一段引流与胃旁路手术有可比的减肥效果。

 本期Nature Communications上发表的一项研究报告说,将小鼠的胆汁向小肠的最后一段引流与胃旁路手术有可比的减肥效果。


Naji Abumrad及同事将肥胖小鼠的胆囊接到小肠的不同部分,并在长达八个星期的一段时间内将该手术所产生的代谢好处与小鼠的RYGB手术直接进行比较。他们发现,将胆汁酸向小肠的最后一部分(回肠)引流,足以产生与更复杂的传统手术方法相似的减肥效果。作者提出,小肠中减少的脂肪吸收与肠道菌群的变化是产生这些效果的部分原因。



Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery


Roux-en-Y gastric bypass (RYGB) is highly effective in reversing obesity and associated diabetes. Recent observations in humans suggest a contributing role of increased circulating bile acids in mediating such effects. Here we use a diet-induced obesity (DIO) mouse model and compare metabolic remission when bile flow is diverted through a gallbladder anastomosis to jejunum, ileum or duodenum (sham control). We find that only bile diversion to the ileum results in physiologic changes similar to RYGB, including sustained improvements in weight, glucose tolerance and hepatic steatosis despite differential effects on hepatic gene expression. Circulating free fatty acids and triglycerides decrease while bile acids increase, particularly conjugated tauro-β-muricholic acid, an FXR antagonist. Activity of the hepatic FXR/FGF15 signalling axis is reduced and associated with altered gut microbiota. Thus bile diversion, independent of surgical rearrangement of the gastrointestinal tract, imparts significant weight loss accompanied by improved glucose and lipid homeostasis that are hallmarks of RYGB.

来源: Nature Communications 浏览次数:0


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