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Sci Rep:兰州大学马建民研究组发表二恶英临界癌症风险研究成果

摘要 : 2016年2月25日,国际学术权威刊物自然出版集团旗下子刊《Scientific Reports》杂志上在线发表了兰州大学资源环境学院黄韬博士的二恶英临界癌症风险研究成果。

 2016年2月25日,国际学术权威刊物自然出版集团旗下子刊《Scientific Reports》杂志上在线发表了兰州大学资源环境学院黄韬博士的二恶英临界癌症风险研究成果“Trend of cancer risk of Chinese inhabitants to dioxins due to changes in dietary patterns: 1980–2009”。黄韬博士为论文第一作者与共同通讯作者,论文另一位通讯作者为马建民教授。

课题组开发和应用一个耦合的有机污染物大气、土壤、水、食物网富集和癌症风险评估模式模拟了自改革开放以来我国居民的二恶英致癌风险。模拟结果显示,自1980年以来,随着我国钢铁冶炼、火力发电、垃圾焚烧等行业经济活动迅速发展,伴随而来的二恶英排放也显著增加。在此期间,由于生活水平提高,我国居民的饮食由粮食和蔬菜为主、少肉食的结构逐渐转为粮食和蔬菜摄入降低、肉食和蛋奶制品显著增加的饮食结构。由于二恶英在环境中难以降解、易富集于高脂肪动物体内,进而通过人体食物链进入人体体内,增加了人类的致癌风险。研究发现,我国居民超过美国环保署推荐的二恶英临界癌症风险的人口比例已从1980年的0.2%增加到2009年的1.2%。

研究结果还揭示,虽然我国居民的动物源食品的平均摄入量仍然低于西方国家,但由于我国二恶英的环境水平明显高于发达国家,由此产生的我国居民的二恶英癌症风险不容忽视。课题组指出,高脂肪饮食结构对我国居民二恶英癌症风险的贡献从1980年的8%增加到2009年的17%。其中我国东部和城镇居民的癌症风险远高于西部和农村地区居民。尽管城市居民因摄入更多的肉食而具有更高二恶英癌症风险,但由于近年来农村居民肉食消费的增长量高于城镇居民,导致其癌症风险增加更加明显。

原文链接:

Trend of cancer risk of Chinese inhabitants to dioxins due to changes in dietary patterns: 1980–2009

原文摘要:

Food ingestion is a major route for human exposure and body burden to dioxins. We estimated the potential influence of changes in dietary patterns in Chinese population on human health risk to 2,3,7,8-TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) over the last three decades. We performed multiple modeling scenario investigations to discriminate the contribution of 2,3,7,8-TCDD emissions and changes in dietary patterns to the cancer risks (CR) to dioxins. Results showed that changes in dietary patterns, featured by decreasing consumption of total grain (including all unprocessed grains) and vegetables and increasing intake of animal-derived foodstuffs, caused increasing CR from 7.3 × 10−8 in 1980 to 1.1 × 10−7 in 2009. Varying dietary patterns contributed 17% to the CR of Chinese population in 2009 under the fixed emission in 1980. The CR to 2,3,7,8-TCDD in urban and eastern China residents was higher considerably than those who lived in rural area and western China, attributable to higher emissions, household income, and greater intake of animal-derived foodstuffs in urban and eastern China inhabitants. On the other hand, more rapid increasing trend of the CR was found in rural residents due to their more rapid increase in the consumption of fat-dominated foods as compared with urban residents.

来源: Scientific Reports 浏览次数:0

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